Publications

 

Key Publications

The following are key publications of GCP faculty and collaborators. For a full list of recent relevant publications, click here. 

 

DeBoer R, Ndumbalo J, Meena S, Ngoma M, Mvungi N, Siu S, Selekwa M, Nyagabona SK, Luhar R, Buckle G, Lin T, Breithaupt L, Kennell-Heiling S, Mushi B, Philipo G, Mmbaga E, Mwaiselage J, Van Loon K. Development of a theory-driven implementation strategy for cancer management guidelines in sub-Saharan Africa. Implementation Science Communications, no. 1, 2020, pp 1-9, doi: 0.1186/s43058-020-00007-7

Despite recent international efforts to develop resource-stratified clinical practice guidelines for cancer, there has been little research to evaluate the best strategies for dissemination and implementation in lowand middle-income countries (LMICs). Guideline publication alone is insufficient. Extensive research has shown that structured, multifaceted implementation strategies that target barriers to guideline use are most likely to improve adherence; however, most of this research has been conducted in high-income countries. There is a pressing need to develop and evaluate guideline implementation strategies for cancer management in LMICs in order to address stark disparities in cancer outcomes.

We developed a robust, multifaceted guideline implementation strategy derived from a prominent behavior change theory for use in Tanzania. The barriers and strategies we generated are consistent with those well established in the literature, enhancing the validity and generalizability of our process and results. Through our rigorous evaluation plan and systematic account of modifications and adaptations, we will characterize the transferability of “proven” guideline implementation strategies to LMICs. We hope that by describing our process in detail, others may endeavor to replicate it, meeting a widespread need for dedicated efforts to implement cancer guidelines in LMICs.

 

Ng, Dianna L., et al. Efficacy of an Intensive, Ultrasound-Guided Fine-Needle Aspiration Biopsy Training Workshop in Tanzania. Journal of Global Oncology, no. 4, 2018, pp. 1–9., doi:10.1200/jgo.18.00134.

Fine-needle aspiration biopsy (FNAB) is a minimally invasive, cost-effective diagnostic tool that can be used in low-resource settings. However, adequacy and accuracy of FNAB is highly dependent on the skills of the operator and requires specialized training. Poor technique can preclude definitive diagnoses because of insufficient quality or quantity of FNAB samples. We evaluated the efficacy of an intensive training experience in Tanzania on improving ultrasound-guided FNAB techniques.

 

Rositch A, Unger-Saldana K, DeBoer R, Ng'ang'a A, Weiner B. The role of dissemination and implementation science in global breast cancer control programs: Frameworks, methods, and examples. Cancer. 2020 Apr 29. doi: 10.1002/cncr.32877

Dissemination and implementation science (D&IS) seeks to understand how to promote the systematic uptake of evidence‐based interventions and/or practices into real‐world contexts. D&IS methods are useful for selecting strategies to implement evidence‐based interventions, adapting their implementation to new settings, and evaluating the implementation process as well as its outcomes to determine success and failure, and adjust accordingly. Process models, explanatory theories, and evaluation frameworks are used in D&IS to develop implementation strategies, identify implementation outcomes, and design studies to evaluate these outcomes. In breast cancer control and management, research has been translated into evidence‐based, resource‐stratified guidelines by the Breast Health Global Initiative and others. D&IS should be leveraged to optimize the implementation of these guidelines, and other evidence‐based interventions, into practice across the breast cancer care continuum, from optimizing public education to promoting early detection, increasing guideline‐concordant clinical practice among providers, and analyzing and addressing barriers and facilitators in health care systems. Stakeholder engagement through processes such as co‐creation is critical. In this article, the authors have provided a primer on the contribution of D&IS to phased implementation of global breast cancer control programs, provided 2 case examples of ongoing D&IS research projects in Tanzania, and concluded with recommendations for best practices for researchers undertaking this work.

 

Rubagumya F, Nyagabona SK, Msami KH, Manirakiza A, Longombe AN, Maniragaba T, Chan H, Paciorek A, Zhang L, Balandya E, Germana LH, Mmbaga EJ, Dharsee N, Van Loon K. Attitudes and Barriers to Research Among Oncology Trainees in East Africa.  Oncologist,  2019 Mar 22. PMID: 30902914. doi: 10.1634/theoncologist.2018-0805

A majority of current or recent oncology trainees in Tanzania desire to incorporate research into their careers, but most also lack adequate training in research methodology and longitudinal mentorship. Current and recent oncology trainees in East Africa expressed a high enthusiasm for research, driven by a sense of urgency related to the burden from cancer that the region faces. This highlights the need for cancer research training and mentorship in this setting. This work hypothesizes that African principal investigators can operate effectively if proper attention is given to selection and provision of high-quality foundational didactic training to learn the theory and implementation of research as well as to the development of an environment conducive to mentoring.

 

Van Loon, K., et al., The African Esophageal Cancer Consortium: A Call to ActionJournal of Global Oncology, no. 4, 2018, pp. 1-9., doi: 10.1200/JGO.17.00163

Esophageal cancer is the eighth most common cancer worldwide and the sixth most common cause of cancer-related death; however, worldwide incidence and mortality rates do not reflect the geographic variations in the occurrence of this disease. In recent years, increased attention has been focused on the high incidence of esophageal squamous cell carcinoma (ESCC) throughout the eastern corridor of Africa, extending from Ethiopia to South Africa. Nascent investigations are underway at a number of sites throughout the region in an effort to improve our understanding of the etiology behind the high incidence of ESCC in this region. In 2017, these sites established the African Esophageal Cancer Consortium. Here, we summarize the priorities of this newly established consortium: to implement coordinated multisite investigations into etiology and identify targets for primary prevention; to address the impact of the clinical burden of ESCC via capacity building and shared resources in treatment and palliative care; and to heighten awareness of ESCC among physicians, at-risk populations, policy makers, and funding agencies.

 


 

Relevant Faculty Publications 

 Ayers LW, Barbachano-Guerrero A, McAllister SC, Ritchie JA, Asiago-Reddy E, Bartlett LC, Cesarman E, Wang D, Rochford R, Martin JN, King CA. Mast Cell Activation and KSHV Infection in Kaposi Sarcoma. Clin Cancer Res. 2018 Oct 15; 24(20):5085-5097. PMID: 30084838.

Atkinson TM, Palefsky J, Li Y, Webb A, Berry JM, Goldstone S, Levine R, Wilkin TJ, Bucher G, Cella D, Burkhalter JE. Reliability and between-group stability of a health-related quality of life symptom index for persons with anal high-grade squamous intraepithelial lesions: an AIDS Malignancy Consortium Study (AMC-A03). Qual Life Res. 2019 Jan 07. PMID: 30617704.

Ayers LW, Barbachano-Guerrero A, McAllister SC, Ritchie JA, Asiago-Reddy E, Bartlett LC, Cesarman E, Wang D, Rochford R, Martin JN, King CA. Mast Cell Activation and KSHV Infection in Kaposi Sarcoma. Clin Cancer Res. 2018 Oct 15; 24(20):5085-5097. PMID: 30084838.

Bhatta DN, Glantz S. Association of E-cigarette use with respiratory disease among adults: A longitudinal analysis. American Journal of Preventative Medicine. 2019 Dec 16. doi: 10.1016/j.amepre.2019.07.28

Bhatta DN, Glantz S. Parental tobacco use and child death: analysis of data from demographic and health surveys from South and South East Asian countries. Int J Epidemiol. 2018 Oct 01. PMID: 30277524.

Bhatta DN, Glantz SA. Electronic Cigarette Use and Myocardial Infarction Among Adults in the US Population Assessment of Tobacco and Health. J Am Heart Assoc. 2019 Jun 18; 8(12):e012317. PMID: 31165662.

Bhatta DN, Hiatt RA, Van Loon K, Glantz SA. Exposure to household tobacco smoke and risk of cancer morbidity and mortality: Analysis of data from the Afghanistan Demographic and Health Survey 2015. Prev Med. 2019 Jun; 123:217-224. PMID: 30940572.

Bialous SA, Van der Eijk Y. How should global tobacco control efforts be prioritized to protect children in resource-por regions?. AMA J Ethics. 2020 Feb; 22(2):E135-146. doi: 10.100/amajethics.2020.135.  

Chinyowa S, Palefsky JM, Chirenje ZM, Makunike-Mutasa R, Munjoma M, Muguti GI. Anal human papillomavirus infection in HIV-positive men and women at two opportunistic infections clinics in Harare, Zimbabwe. BMC Public Health. 2018 Nov 14; 18(1):1260. PMID: 30428859.

Cho HJ, Dutra LM, Glantz SA. Differences in Adolescent E-cigarette and Cigarette Prevalence in Two Policy Environments: South Korea and the United States. Nicotine Tob Res. 2018 Jul 9;20(8):949-953. doi: 10.1093/ntr/ntx198.

DeBoer R, Ndumbalo J, Meena S, Ngoma M, Mvungi N, Siu S, Selekwa M, Nyagabona SK, Luhar R, Buckle G, Lin T, Breithaupt L, Kennell-Heiling S, Mushi B, Philipo G, Mmbaga E, Mwaiselage J, Van Loon K. Developement of a theory-driven implementation strategy for cancer management guidelines in sub-Saharan Africa. Implementation Science Communications. 2020 Feb; 1(0): 1-9, doi: 0.1186/s43058-020-00007-7

Egbe CO, Bialous SA, Glantz S. Framework Convention on Tobacco Control Implementation in Nigeria: Lessons for Low- and Middle-Income Countries. Nicotine Tob Res. 2019 Jul 17;21(8):1122-1130. doi: 10.1093/ntr/nty069.

Egbe CO, Bialous SA, Glantz S. Role of stakeholders in Nigeria's tobacco control journey after the FCTC: lessons for tobacco control advocacy in low-income and middle-income countries. Tob Control. 2019 Jul;28(4):386-393. doi: 10.1136/tobaccocontrol-2018-054344. Epub 2018 Jul 25.

Einstein MH, Ndlovu N, Lee J, Stier EA, Kotzen J, Garg M, Whitney K, Lensing SY, Tunmer M, Kadzatsa W, Palefsky J, Krown SE. Cisplatin and radiation therapy in HIV-positive women with locally advanced cervical cancer in sub-Saharan Africa: A phase II study of the AIDS malignancy consortium. Gynecol Oncol. 2019 04; 153(1):20-25. PMID: 30773222.

Harding R, Nair S, Ekstrand M. Multilevel model of stigma and barriers to cancer palliative care in India: a qualitative study. BMJ Open. 2019 Mar 04; 9(3):e024248. PMID: 30837250.

Hosseinipour MC, Kang M, Krown SE, Bukuru A, Umbleja T, Martin JN, Orem J, Godfrey C, Hoagland B, Mwelase N, Langat D, Nyirenda M, MacRae J, Borok M, Samaneka W, Moses A, Mngqbisa R, Busakhala N, Martínez-Maza O, Ambinder R, Dittmer DP, Nokta M, Campbell TB. As-Needed Vs Immediate Etoposide Chemotherapy in Combination With Antiretroviral Therapy for Mild-to-Moderate AIDS-Associated Kaposi Sarcoma in Resource-Limited Settings: A5264/AMC-067 Randomized Clinical Trial. Clin Infect Dis. 2018 Jul 02; 67(2):251-260. PMID: 29365083.

Huchko MJ, Ibrahim S, Blat C, Cohen CR, Smith JS, Hiatt RA, Bukusi E. Cervical cancer screening through human papillomavirus testing in community health campaigns versus health facilities in rural western Kenya. Int J Gynaecol Obstet. 2018 Apr; 141(1):63-69. PMID: 29197067.

Mmbaga EJ, Deardorff KV, Mushi B, Mgisha W, Merritt M, Hiatt RA, Mwaiselage J, Zhang L, Van Loon K. Characteristics of Esophageal Cancer Cases in Tanzania. J Glob Oncol. 2018 Sep; 4:1-10. PMID:30241222.

Morrissey, L., et al., Disparities in the Delivery of Pediatric Oncology Nursing Care by Country Income Classification: International Survey Results. Journal of Pediatric Blood and Cancer,  doi: 10.1002/pbc.27663

Mudini W, Palefsky JM, Hale MJ, Chirenje MZ, Makunike-Mutasa R, Mutisi F, Murahwa A, Mario A. Human Papillomavirus Genotypes in Invasive Cervical Carcinoma in HIV-Seropositive and HIV-Seronegative Women in Zimbabwe. J Acquir Immune Defic Syndr. 2018 Sep 01; 79(1):e1-e6. PMID: 29781877.

Mutebi M, Anderson B, Duggan C, Adebamowo C, Agarwal G, Ali Z, Bird P, Bourque JM, DeBoer R, Gebrim LH, Masetti R, Masson S, Menon M, Nakigudde G, Ng'ang'a A, Niyonzima N, Rositch A, Unger-Sldana K, Villarreal-Garza C, Dvaldze A, El Saghir N, Gralow J. Breast cancer treatment : A phased approach to implementation. Cancer. 2020 Apr 29; 126 (S10): 2365-78. doi:10.1002/cncr.32910

Ng, Dianna L., et al. Efficacy of an Intensive, Ultrasound-Guided Fine-Needle Aspiration Biopsy Training Workshop in Tanzania. Journal of Global Oncology, no. 4, 2018, pp. 1–9., doi:10.1200/jgo.18.00134.

Remes-Troche JM, Hinojosa-Garza G, Espinosa-Tamez P, Meixueiro-Daza A, Grube-Pagola P, Van Loon K, Potter M, Lajous M.  Faecal immunochemical test-based colorectal cancer screening in Mexico: an initial experience. Family Practice, 2020 Jan 21. doi.org/10.1093/fampra/cmz078. 

Rositch A, Unger-Saldana K, DeBoer R, Ng'ang'a A, Weiner B. The role of dissemination and implementation science in global breast cancer control programs: Frameworks, methods, and examples. Cancer, 2020 Apr 29. doi.org/10.1002/cncer.32877 

Rubagumya F, Nyagabona SK, Msami KH, Manirakiza A, Longombe AN, Maniragaba T, Chan H, Paciorek A, Zhang L, Balandya E, Germana LH, Mmbaga EJ, Dharsee N, Van Loon K. Attitudes and Barriers to Research Among Oncology Trainees in East Africa.  Oncologist,  2019 Mar 22. PMID: 30902914. doi: 10.1634/theoncologist.2018-0805

Samwel K, Kahesa C, Mwaiselage J, Gonzalez D, West JT, Wood C, Palefsky J, Angeletti PC. Analytical performance of a low-cost multiplex polymerase chain reaction human papillomavirus genotyping assay for use in Sub-Saharan Africa. J Med Virol. 2019 Feb; 91(2):308-316. PMID: 30281790.

Shin SS, Carpenter CL, Ekstrand ML, Wang Q, Grover S, Zetola NM, Yadav K, Sinha S, Nyamathi AM. Cervical cancer awareness and presence of abnormal cytology among HIV-infected women on antiretroviral therapy in rural Andhra Pradesh, India. Int J STD AIDS. 2019 May; 30(6):586-595. PMID: 30813859.

Tamayo LI, Vidaurre T, Navarro Vásquez J, Casavilca S, Aramburu Palomino JI, Calderon M, Abugattas JE, Gomez HL, Castaneda CA, Song S, Cherry D, Rauscher GH, Fejerman L. Breast cancer subtype and survival among Indigenous American women in Peru. PLoS One. 2018; 13(9):e0201287. PMID: 30183706.

Van Loon, K., et al., The African Esophageal Cancer Consortium: A Call to Action. Journal of Global Oncology, no. 4, 2018, pp. 1-9., doi: 10.1200/JGO.17.00163.

Williamson AL, Garland S, Palefsky J, Rybicki E, Stanley M, de Sanjosé S. The Cape Town declaration on human papillomavirus related disease. Papillomavirus Res. 2018 06; 5:59-60. PMID: 29294358.

Xu M, Su D, DeBoer R, Garcia M, Tahir P, Anderson W, Kinderman A, Braunstein S, Sheretz T. Palliative Oncologic Care Curricula for Providers in Resource-Limited and Underserved Communities: A Systematic Review. J Cancer Educ. 2019 Apr; 34(2):205-215. PMID: 29264703

Zavala VA, Serrano-Gomez SJ, Dutil J, Fejerman L. Genetic Epidemiology of Breast Cancer in Latin America. Genes (Basel). 2019 Feb 18; 10(2). PMID: 30781715.