Michelle Hermiston, MD, PhD

Associate Professor in Res
Pediatrics
+1 415 476-2413
Publications: 

Manipulating DNA damage-response signaling for the treatment of immune-mediated diseases.

Proceedings of the National Academy of Sciences of the United States of America

McNally JP, Millen SH, Chaturvedi V, Lakes N, Terrell CE, Elfers EE, Carroll KR, Hogan SP, Andreassen PR, Kanter J, Allen CE, Henry MM, Greenberg JN, Ladisch S, Hermiston ML, Joyce M, Hildeman DA, Katz JD, Jordan MB

JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias.

Leukemia

Delgado-Martin C, Meyer LK, Huang BJ, Shimano KA, Zinter MS, Nguyen JV, Smith GA, Taunton J, Winter SS, Roderick JR, Kelliher MA, Horton TM, Wood BL, Teachey DT, Hermiston ML

Targeting childhood, adolescent and young adult non-Hodgkin lymphoma: therapeutic horizons.

British journal of haematology

Galardy PJ, Bedekovics T, Hermiston ML

MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia.

Blood

Jones CL, Gearheart CM, Fosmire S, Delgado-Martin C, Evensen NA, Bride K, Waanders AJ, Pais F, Wang J, Bhatla T, Bitterman DS, de Rijk SR, Bourgeois W, Dandekar S, Park E, Burleson TM, Madhusoodhan PP, Teachey DT, Raetz EA, Hermiston ML, Müschen M, Loh ML, Hunger SP, Zhang J, Garabedian MJ, Porter CC, Carroll WL

Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production.

Journal of immunology (Baltimore, Md. : 1950)

Mills RE, Lam VC, Tan A, Cresalia N, Oksenberg N, Zikherman J, Anderson M, Weiss A, Hermiston ML

Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia.

Blood

Maude SL, Dolai S, Delgado-Martin C, Vincent T, Robbins A, Selvanathan A, Ryan T, Hall J, Wood AC, Tasian SK, Hunger SP, Loh ML, Mullighan CG, Wood BL, Hermiston ML, Grupp SA, Lock RB, Teachey DT

A(nother) RAF mutation in LCH.

Blood

Shannon K, Hermiston M

The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.

Journal of immunology (Baltimore, Md. : 1950)

Zikherman J, Parameswaran R, Hermiston M, Weiss A

Initially disadvantaged, TEL-AML1 cells expand and initiate leukemia in response to irradiation and cooperating mutations.

Leukemia

Li M, Jones L, Gaillard C, Binnewies M, Ochoa R, Garcia E, Lam V, Wei G, Yang W, Lobe C, Hermiston M, Passegué E, Kogan SC

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.

Nature

Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick DJ, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert K, Laurenti E, Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore KP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenauer JC, Evans WE, Pui CH, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR, Mullighan CG

Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response.

Science translational medicine

Wang X, Takagawa J, Lam VC, Haddad DJ, Tobler DL, Mok PY, Zhang Y, Clifford BT, Pinnamaneni K, Saini SA, Su R, Bartel MJ, Sievers RE, Carbone L, Kogan S, Yeghiazarians Y, Hermiston M, Springer ML

PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.

Journal of immunology (Baltimore, Md. : 1950)

Zikherman J, Hermiston M, Steiner D, Hasegawa K, Chan A, Weiss A

Requirement for CD45 in fine-tuning mast cell responses mediated by different ligand-receptor systems.

Cellular signalling

Grochowy G, Hermiston ML, Kuhny M, Weiss A, Huber M

Oncogenic Kras initiates leukemia in hematopoietic stem cells.

PLoS biology

Sabnis AJ, Cheung LS, Dail M, Kang HC, Santaguida M, Hermiston ML, Passegué E, Shannon K, Braun BS

Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses.

Proceedings of the National Academy of Sciences of the United States of America

Hermiston ML, Zikherman J, Tan AL, Lam VC, Cresalia NM, Oksenberg N, Goren N, Brassat D, Oksenberg JR, Weiss A

B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency.

The Journal of experimental medicine

Gupta VA, Hermiston ML, Cassafer G, Daikh DI, Weiss A

Epstein-Barr virus-associated B cell lymphoproliferative disease in a child with neonatal-onset multisystem inflammatory disease.

Arthritis and rheumatism

Modica R, Emery H, Lam W, Hermiston M, Grenert J, Wirt M, von Scheven E

Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production.

Proceedings of the National Academy of Sciences of the United States of America

Hesslein DG, Takaki R, Hermiston ML, Weiss A, Lanier LL

The juxtamembrane wedge negatively regulates CD45 function in B cells.

Immunity

Hermiston ML, Tan AL, Gupta VA, Majeti R, Weiss A

A practical approach to the evaluation of the anemic child.

Pediatric clinics of North America

Hermiston ML, Mentzer WC

Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases.

The Journal of clinical investigation

Hermiston ML, Xu Z, Majeti R, Weiss A

CD45: a critical regulator of signaling thresholds in immune cells.

Annual review of immunology

Hermiston ML, Xu Z, Weiss A

Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene.

Nature

Fazeli A, Dickinson SL, Hermiston ML, Tighe RV, Steen RG, Small CG, Stoeckli ET, Keino-Masu K, Masu M, Rayburn H, Simons J, Bronson RT, Gordon JI, Tessier-Lavigne M, Weinberg RA

Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium.

Proceedings of the National Academy of Sciences of the United States of America

Wong MH, Hermiston ML, Syder AJ, Gordon JI

Differentiation and self-renewal in the mouse gastrointestinal epithelium.

Current opinion in cell biology

Gordon JI, Hermiston ML

Chimeric-transgenic mice represent a powerful tool for studying how the proliferation and differentiation programs of intestinal epithelial cell lineages are regulated.

Proceedings of the National Academy of Sciences of the United States of America

Hermiston ML, Green RP, Gordon JI

Simultaneous localization of six antigens in single sections of transgenic mouse intestine using a combination of light and fluorescence microscopy.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Hermiston ML, Latham CB, Gordon JI, Roth KA

Use of transgenic mice to infer the biological properties of small intestinal stem cells and to examine the lineage relationships of their descendants.

Proceedings of the National Academy of Sciences of the United States of America

Roth KA, Hermiston ML, Gordon JI

Isolation of mutants defective in early steps of meiotic recombination in the yeast Saccharomyces cerevisiae.

Genetics

Malone RE, Bullard S, Hermiston M, Rieger R, Cool M, Galbraith A