Marc Shuman, MD

PROFESSOR EMERITUS
Medicine
+1 415 476-2125
Publications: 

Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells.

The Journal of clinical investigation

Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA, Wu X, Atkinson JP, Wolf JL, Martin TG, Liu B

EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.

Nature neuroscience

Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, Weiss WA, James CD, Shuman MA, Bader GD, Mueller S, Taylor MD, Jan YN, Jan LY

Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kadoch C, Li J, Wong VS, Chen L, Cha S, Munster P, Lowell CA, Shuman MA, Rubenstein JL

Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma.

Blood

Rubenstein JL, Li J, Chen L, Advani R, Drappatz J, Gerstner E, Batchelor T, Krouwer H, Hwang J, Auerback G, Kadoch C, Lowell C, Munster P, Cha S, Shuman MA, Damon LE

Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.

Genes & development

Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY

Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI.

Clinical cancer research : an official journal of the American Association for Cancer Research

Wieduwilt MJ, Valles F, Issa S, Behler CM, Hwang J, McDermott M, Treseler P, O'Brien J, Shuman MA, Cha S, Damon LE, Rubenstein JL

Upregulation of Cyclin B1 by miRNA and its implications in cancer.

Nucleic acids research

Huang V, Place RF, Portnoy V, Wang J, Qi Z, Jia Z, Yu A, Shuman M, Yu J, Li LC

Time-resolved single-step protease activity quantification using nanoplasmonic resonator sensors.

ACS nano

Sun C, Su KH, Valentine J, Rosa-Bauza YT, Ellman JA, Elboudwarej O, Mukherjee B, Craik CS, Shuman MA, Chen FF, Zhang X

The unfolded protein response during prostate cancer development.

Cancer metastasis reviews

So AY, de la Fuente E, Walter P, Shuman M, Bernales S

Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kadoch C, Dinca EB, Voicu R, Chen L, Nguyen D, Parikh S, Karrim J, Shuman MA, Lowell CA, Treseler PA, James CD, Rubenstein JL

Differential gene expression in central nervous system lymphoma.

Blood

Rubenstein JL, Shen A, Batchelor TT, Kadoch C, Treseler P, Shuman MA

Protein biomarker identification in the CSF of patients with CNS lymphoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Roy S, Josephson SA, Fridlyand J, Karch J, Kadoch C, Karrim J, Damon L, Treseler P, Kunwar S, Shuman MA, Jones T, Becker CH, Schulman H, Rubenstein JL

Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Rubenstein JL, Fridlyand J, Abrey L, Shen A, Karch J, Wang E, Issa S, Damon L, Prados M, McDermott M, O'Brien J, Haqq C, Shuman M

The epidemiology of prostate cancer--with a focus on nonsteroidal anti-inflammatory drugs.

Hematology/oncology clinics of North America

Chan JM, Feraco A, Shuman M, Hernández-Díaz S

Gene expression and angiotropism in primary CNS lymphoma.

Blood

Rubenstein JL, Fridlyand J, Shen A, Aldape K, Ginzinger D, Batchelor T, Treseler P, Berger M, McDermott M, Prados M, Karch J, Okada C, Hyun W, Parikh S, Haqq C, Shuman M

Symposium on androgen action in prostate cancer.

Cancer research

Tindall D, Horne FM, Hruszkewycz A, Mohla S, Shuman M, Wang Z, Kantoff P

Quinine/quinidine-induced thrombocytopenia: a great imitator.

Archives of internal medicine

Reddy JC, Shuman MA, Aster RH

Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells.

Biological chemistry

Bhatt AS, Takeuchi T, Ylstra B, Ginzinger D, Albertson D, Shuman MA, Craik CS

Patterns of protease production during prostate cancer progression: proteomic evidence for cascades in a transgenic model.

Prostate cancer and prostatic diseases

Bok RA, Hansell EJ, Nguyen TP, Greenberg NM, McKerrow JH, Shuman MA

Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment.

Blood

Rubenstein JL, Combs D, Rosenberg J, Levy A, McDermott M, Damon L, Ignoffo R, Aldape K, Shen A, Lee D, Grillo-Lopez A, Shuman MA

Hemorrhage and VEGF expression in a case of primary CNS lymphoma.

Journal of neuro-oncology

Rubenstein J, Fischbein N, Aldape K, Burton E, Shuman M

Urokinase plasminogen activator amino-terminal peptides inhibit development of the rat ventral prostate.

Differentiation; research in biological diversity

Elfman F, Bok R, Conn M, Shuman M, Cunha G

Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption.

Neoplasia (New York, N.Y.)

Rubenstein JL, Kim J, Ozawa T, Zhang M, Westphal M, Deen DF, Shuman MA

Interferon-induced thrombocytopenia: is it time for thrombopoietin.

Hepatology (Baltimore, Md.)

Martin TG, Shuman MA

Death-defying yeast identify novel apoptosis genes.

Cell

Shaham S, Shuman MA, Herskowitz I

Thrombopoietin levels in patients with cirrhosis before and after orthotopic liver transplantation.

Annals of internal medicine

Martin TG, Somberg KA, Meng YG, Cohen RL, Heid CA, de Sauvage FJ, Shuman MA

Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice.

Cancer research

Min HY, Doyle LV, Vitt CR, Zandonella CL, Stratton-Thomas JR, Shuman MA, Rosenberg S

Thrombin increases expression of urokinase receptor by activation of the thrombin receptor.

Investigative ophthalmology & visual science

Yang Z, Cohen RL, Lui GM, Lawrence DA, Shuman MA

Serum ferritin levels correlate with disease activity in patients with AIDS and disseminated histoplasmosis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Kirn DH, Fredericks D, McCutchan JA, Stites D, Shuman M

Marked elevation of the serum ferritin is highly specific for disseminated histoplasmosis in AIDS.

AIDS (London, England)

Kirn DH, Fredericks D, McCutchan JA, Stites D, Shuman M

Immunohistochemical localization of the plasminogen activator inhibitor-1 in breast cancer.

International journal of cancer

Bianchi E, Cohen RL, Dai A, Thor AT, Shuman MA, Smith HS

Characterization of a human Kaposi's sarcoma cell line that induces angiogenic tumors in animals.

AIDS (London, England)

Herndier BG, Werner A, Arnstein P, Abbey NW, Demartis F, Cohen RL, Shuman MA, Levy JA

The urokinase receptor is expressed in invasive breast cancer but not in normal breast tissue.

Cancer research

Bianchi E, Cohen RL, Thor AT, Todd RF, Mizukami IF, Lawrence DA, Ljung BM, Shuman MA, Smith HS

Prevention of metastasis by inhibition of the urokinase receptor.

Proceedings of the National Academy of Sciences of the United States of America

Crowley CW, Cohen RL, Lucas BK, Liu G, Shuman MA, Levinson AD

Kistrin, an integrin antagonist, blocks endocytosis of fibrinogen into guinea pig megakaryocyte and platelet alpha-granules.

The Journal of clinical investigation

Handagama P, Bainton DF, Jacques Y, Conn MT, Lazarus RA, Shuman MA

Human platelets and megakaryocytes contain alternately spliced glycoprotein IIb mRNAs.

The Journal of biological chemistry

Bray PF, Leung CS, Shuman MA

A nonradioactive assay for type IV collagen degradation.

Analytical biochemistry

Wilkinson MJ, Cohen RL, Shuman MA

The origin of platelet alpha-granule proteins.

Progress in clinical and biological research

Handagama PJ, Shuman MA, Bainton DF

Anaphylactoid reactions to vascular graft material presenting with vasodilation and subsequent disseminated intravascular coagulation.

Anesthesiology

Roizen MF, Rodgers GM, Valone FH, Lampe GH, Benefiel DJ, Gelman S, Rapp J, Weiler JM, Ota M, Shuman MA

Immunogold-surface replica study of ADP-induced ligand binding and fibrinogen receptor clustering in human platelets.

The American journal of anatomy

Isenberg WM, McEver RP, Phillips DR, Shuman MA, Bainton DF

Effects of cellular transformation on expression of plasminogen activator inhibitors 1 and 2. Evidence for independent regulation.

The Journal of biological chemistry

Cohen RL, Niclas J, Lee WM, Wun TC, Crowley CW, Levinson AD, Sadler JE, Shuman MA

Physical linkage of the genes for platelet membrane glycoproteins IIb and IIIa.

Proceedings of the National Academy of Sciences of the United States of America

Bray PF, Barsh G, Rosa JP, Luo XY, Magenis E, Shuman MA

Development of antithrombin antibodies following surgery in patients with prosthetic cardiac valves.

Blood

Stricker RB, Lane PK, Leffert JD, Rodgers GM, Shuman MA, Corash L

Cloning of glycoprotein IIIa cDNA from human erythroleukemia cells and localization of the gene to chromosome 17.

Blood

Rosa JP, Bray PF, Gayet O, Johnston GI, Cook RG, Jackson KW, Shuman MA, McEver RP

Tissue plasminogen activator in cultured human trabecular meshwork cells. Predominance of enzyme over plasminogen activator inhibitor.

Investigative ophthalmology & visual science

Shuman MA, Polansky JR, Merkel C, Alvarado JA

Platelet glycoprotein IIb. Chromosomal localization and tissue expression.

The Journal of clinical investigation

Bray PF, Rosa JP, Johnston GI, Shiu DT, Cook RG, Lau C, Kan YW, McEver RP, Shuman MA

Prophylactic heparin in APL.

Blood

Venook AP, Shuman MA, Corash L

The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering.

The Journal of cell biology

Isenberg WM, McEver RP, Phillips DR, Shuman MA, Bainton DF

Incorporation of a circulating protein into megakaryocyte and platelet granules.

Proceedings of the National Academy of Sciences of the United States of America

Handagama PJ, George JN, Shuman MA, McEver RP, Bainton DF

Localization of the gene for coagulation factor XIII a-chain to chromosome 6 and identification of sites of synthesis.

The Journal of clinical investigation

Weisberg LJ, Shiu DT, Greenberg CS, Kan YW, Shuman MA

Congenital thrombotic disorders.

American journal of hematology

Rodgers GM, Shuman MA

Biogenesis of the platelet receptor for fibrinogen: evidence for separate precursors for glycoproteins IIb and IIIa.

Proceedings of the National Academy of Sciences of the United States of America

Bray PF, Rosa JP, Lingappa VR, Kan YW, McEver RP, Shuman MA

Thrombin-cellular interactions.

Annals of the New York Academy of Sciences

Shuman MA

Urokinase binding to bovine corneal endothelial cells.

Experimental eye research

Shuman MA, Merkel CH

A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation.

The Journal of cell biology

Stenberg PE, McEver RP, Shuman MA, Jacques YV, Bainton DF

Detection and sequence of mutations in the factor VIII gene of haemophiliacs.

Nature

Gitschier J, Wood WI, Tuddenham EG, Shuman MA, Goralka TM, Chen EY, Lawn RM

Cleavage of blood coagulation factor XIII and fibrinogen by thrombin during in vitro clotting.

The Journal of clinical investigation

Greenberg CS, Miraglia CC, Rickles FR, Shuman MA

Redistribution of alpha-granules and their contents in thrombin-stimulated platelets.

The Journal of cell biology

Stenberg PE, Shuman MA, Levine SP, Bainton DF

Prothrombin is activated on vascular endothelial cells by factor Xa and calcium.

Proceedings of the National Academy of Sciences of the United States of America

Rodgers GM, Shuman MA

Radioisotopic measurement of plasma kallikrein.

Thrombosis research

Rodgers GM, Donaldson VH, Shuman MA

Acquired cyclic neutropenia: successful treatment with prednisone.

American journal of hematology

Rodgers GM, Shuman MA

Proliferation and differentiation of bovine corneal endothelial cells in culture.

Metabolic, pediatric, and systemic ophthalmology

Savion N, Isaacs JD, Shuman MA, Gospodarowicz D

Effect of cell density on thrombin binding to a specific site on bovine vascular endothelial cells.

The Journal of cell biology

Isaacs J, Savion N, Gospodarowicz D, Shuman MA

Internalization and degradation of thrombin and up regulation of thrombin-binding sites in corneal endothelial cells.

The Journal of biological chemistry

Savion N, Isaacs JD, Gospodarowicz D, Shuman MA

Covalent binding of thrombin to specific sites on corneal endothelial cells.

Biochemistry

Isaacs JD, Savion N, Gospodarowicz D, Fenton JW, Shuman MA

Combined idiopathic neutropenia and thrombocytopenia: evidence for an immune basis for the syndrome.

Annals of internal medicine

Linker CA, Newcom SR, Nilsson CM, Wolf JL, Shuman MA

Synthesis of plasminogen activator by bovine corneal endothelial cells.

Experimental eye research

Fehrenbacher L, Gospodarowicz D, Shuman MA

Thrombin-induced platelet secretion. Further evidence for a specific pathway.

The Journal of clinical investigation

Shuman MA, Botney M, Fenton JW

Thrombin generation and secretion of platelet Factor 4 during blood clotting.

The Journal of clinical investigation

Shuman MA, Levine SP

The measurement of thrombin in clotting blood by radioimmunoassay.

The Journal of clinical investigation

Shuman MA, Majerus PW

The binding of human and bovine thrombin to human platelets.

Blood

Shuman MA, Tollefsen DM, Majerus PW

Letter: Polycythemia vera and acute leukemia.

Annals of internal medicine

Neu LT, Shuman MA, Brown EB

The perturbation of thrombin binding to human platelets by anions.

The Journal of clinical investigation

Shuman MA, Majerus PW

Characteristics of the membrane defect in the hereditary stomatocytosis syndrome.

Blood

Wiley JS, Ellory JC, Shuman MA, Shaller CC, Cooper RA