PROFESSOR EMERITUS
M_MED-CORE-HMON-ONCO-GEN
+1 415 476-2125
Publications
Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells.
The Journal of clinical investigation
EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.
Nature neuroscience
WITHDRAWN: Enhanced Detection and Phenotypic and Karyotypic in Situ Characterization of Circulating Tumor Cells.
The American journal of pathology
Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.
Genes & development
Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI.
Clinical cancer research : an official journal of the American Association for Cancer Research
Upregulation of Cyclin B1 by miRNA and its implications in cancer.
Nucleic acids research
Time-resolved single-step protease activity quantification using nanoplasmonic resonator sensors.
ACS nano
The unfolded protein response during prostate cancer development.
Cancer metastasis reviews
Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model.
Clinical cancer research : an official journal of the American Association for Cancer Research
Protein biomarker identification in the CSF of patients with CNS lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
The epidemiology of prostate cancer--with a focus on nonsteroidal anti-inflammatory drugs.
Hematology/oncology clinics of North America
Symposium on androgen action in prostate cancer.
Cancer research
Quinine/quinidine-induced thrombocytopenia: a great imitator.
Archives of internal medicine
Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells.
Biological chemistry
Patterns of protease production during prostate cancer progression: proteomic evidence for cascades in a transgenic model.
Prostate cancer and prostatic diseases
Hemorrhage and VEGF expression in a case of primary CNS lymphoma.
Journal of neuro-oncology
Urokinase plasminogen activator amino-terminal peptides inhibit development of the rat ventral prostate.
Differentiation; research in biological diversity
Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption.
Neoplasia (New York, N.Y.)
Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue.
Proceedings of the National Academy of Sciences of the United States of America
Neutralizing anti-vascular endothelial growth factor antibody inhibits further growth of established prostate cancer and metastases in a pre-clinical model.
The Journal of urology
Interferon-induced thrombocytopenia: is it time for thrombopoietin.
Hepatology (Baltimore, Md.)
Decreased prostate cancer cell migration by inhibition of the insulin-like growth factor II/Mannose-6-Phosphate receptor.
Urologic oncology
Inhibition of prostate cancer neovascularization and growth by urokinase-plasminogen activator receptor blockade.
Cancer research
Thrombopoietin levels in patients with cirrhosis before and after orthotopic liver transplantation.
Annals of internal medicine
Circulating thrombopoietin concentrations in thrombocytopenic patients, including cancer patients following chemotherapy, with or without peripheral blood progenitor cell transplantation.
British journal of haematology
Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice.
Cancer research
Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth.
Cancer research
Marked elevation of the serum ferritin is highly specific for disseminated histoplasmosis in AIDS.
AIDS (London, England)
Serum ferritin levels correlate with disease activity in patients with AIDS and disseminated histoplasmosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Thrombin increases expression of urokinase receptor by activation of the thrombin receptor.
Investigative ophthalmology & visual science
Immunohistochemical localization of the plasminogen activator inhibitor-1 in breast cancer.
International journal of cancer
Co-expression of urokinase, urokinase receptor and PAI-1 is necessary for optimum invasiveness of cultured lung cancer cells.
International journal of cancer
Characterization of a human Kaposi's sarcoma cell line that induces angiogenic tumors in animals.
AIDS (London, England)
The urokinase receptor is expressed in invasive breast cancer but not in normal breast tissue.
Cancer research
Prevention of metastasis by inhibition of the urokinase receptor.
Proceedings of the National Academy of Sciences of the United States of America
Kistrin, an integrin antagonist, blocks endocytosis of fibrinogen into guinea pig megakaryocyte and platelet alpha-granules.
The Journal of clinical investigation
In vivo defibrination results in markedly decreased amounts of fibrinogen in rat megakaryocytes and platelets.
The American journal of pathology
Human platelets and megakaryocytes contain alternately spliced glycoprotein IIb mRNAs.
The Journal of biological chemistry
Differential effect of platelets on plasminogen activation by tissue plasminogen activator, urokinase, and streptokinase.
Thrombosis research
A nonradioactive assay for type IV collagen degradation.
Analytical biochemistry
The origin of platelet alpha-granule proteins.
Progress in clinical and biological research
Anaphylactoid reactions to vascular graft material presenting with vasodilation and subsequent disseminated intravascular coagulation.
Anesthesiology
Incorporation of intravenously injected albumin, immunoglobulin G, and fibrinogen in guinea pig megakaryocyte granules.
The Journal of clinical investigation
Immunogold-surface replica study of ADP-induced ligand binding and fibrinogen receptor clustering in human platelets.
The American journal of anatomy
Effects of cellular transformation on expression of plasminogen activator inhibitors 1 and 2. Evidence for independent regulation.
The Journal of biological chemistry
Physical linkage of the genes for platelet membrane glycoproteins IIb and IIIa.
Proceedings of the National Academy of Sciences of the United States of America
Development of antithrombin antibodies following surgery in patients with prosthetic cardiac valves.
Blood
Tissue plasminogen activator in cultured human trabecular meshwork cells. Predominance of enzyme over plasminogen activator inhibitor.
Investigative ophthalmology & visual science
Platelet glycoprotein IIb. Chromosomal localization and tissue expression.
The Journal of clinical investigation
The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering.
The Journal of cell biology
Incorporation of a circulating protein into megakaryocyte and platelet granules.
Proceedings of the National Academy of Sciences of the United States of America
Localization of the gene for coagulation factor XIII a-chain to chromosome 6 and identification of sites of synthesis.
The Journal of clinical investigation
Enhancement of prothrombin activation on platelets by endothelial cells and mechanism of activation of factor V.
Thrombosis research
Congenital thrombotic disorders.
American journal of hematology
Biogenesis of the platelet receptor for fibrinogen: evidence for separate precursors for glycoproteins IIb and IIIa.
Proceedings of the National Academy of Sciences of the United States of America
Thrombin-cellular interactions.
Annals of the New York Academy of Sciences
A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation.
The Journal of cell biology
Acquired Bernard-Soulier syndrome. Evidence for the role of a 210,000-molecular weight protein in the interaction of platelets with von Willebrand factor.
The Journal of clinical investigation
Urokinase binding to bovine corneal endothelial cells.
Experimental eye research
Cleavage of blood coagulation factor XIII and fibrinogen by thrombin during in vitro clotting.
The Journal of clinical investigation
Characterization of the interaction between factor Xa and bovine aortic endothelial cells.
Biochimica et biophysica acta
Specific binding of blood coagulation factor XIIIa to thrombin-stimulated platelets.
The Journal of biological chemistry
Optimal techniques for the immunocytochemical demonstration of beta-thromboglobulin, platelet factor 4, and fibrinogen in the alpha granules of unstimulated platelets.
The Histochemical journal
Aplastic anemia complicating systemic lupus erythematosus: response to androgens in two patients.
American journal of hematology
Redistribution of alpha-granules and their contents in thrombin-stimulated platelets.
The Journal of cell biology
Prothrombin is activated on vascular endothelial cells by factor Xa and calcium.
Proceedings of the National Academy of Sciences of the United States of America
Characterization of the effects of cultured vascular cells on the activation of blood coagulation.
Blood
Radioisotopic measurement of plasma kallikrein.
Thrombosis research
Acquired cyclic neutropenia: successful treatment with prednisone.
American journal of hematology
The zymogen forms of blood coagulation factor XIII bind specifically to fibrinogen.
The Journal of biological chemistry
Proliferation and differentiation of bovine corneal endothelial cells in culture.
Metabolic, pediatric, and systemic ophthalmology
Effect of cell density on thrombin binding to a specific site on bovine vascular endothelial cells.
The Journal of cell biology
Internalization and degradation of thrombin and up regulation of thrombin-binding sites in corneal endothelial cells.
The Journal of biological chemistry
Combined idiopathic neutropenia and thrombocytopenia: evidence for an immune basis for the syndrome.
Annals of internal medicine
Relationship between secretion of platelet Factor 4 and thrombin generation during in vitro blood clotting.
The Journal of clinical investigation
Synthesis of plasminogen activator by bovine corneal endothelial cells.
Experimental eye research
Thrombin-induced platelet secretion. Further evidence for a specific pathway.
The Journal of clinical investigation
Thrombin generation and secretion of platelet Factor 4 during blood clotting.
The Journal of clinical investigation
The measurement of thrombin in clotting blood by radioimmunoassay.
The Journal of clinical investigation
Letter: Polycythemia vera and acute leukemia.
Annals of internal medicine
The perturbation of thrombin binding to human platelets by anions.
The Journal of clinical investigation