Marc Shuman, MD

Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer.

JCI insight

Su Y, Liu Y, Behrens CR, Bidlingmaier S, Lee NK, Aggarwal R, Sherbenou DW, Burlingame AL, Hann BC, Simko JP, Premasekharan G, Paris PL, Shuman MA, Seo Y, Small EJ, Liu B

Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells.

The Journal of clinical investigation

Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA, Wu X, Atkinson JP, Wolf JL, Martin TG, Liu B

EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.

Nature neuroscience

Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, Weiss WA, James CD, Shuman MA, Bader GD, Mueller S, Taylor MD, Jan YN, Jan LY

WITHDRAWN: Enhanced Detection and Phenotypic and Karyotypic in Situ Characterization of Circulating Tumor Cells.

The American journal of pathology

Ge F, Wang DD, Li L, Lin PP, Shuman MA

Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kadoch C, Li J, Wong VS, Chen L, Cha S, Munster P, Lowell CA, Shuman MA, Rubenstein JL

Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma.

Blood

Rubenstein JL, Li J, Chen L, Advani R, Drappatz J, Gerstner E, Batchelor T, Krouwer H, Hwang J, Auerback G, Kadoch C, Lowell C, Munster P, Cha S, Shuman MA, Damon LE

Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.

Genes & development

Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY

Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI.

Clinical cancer research : an official journal of the American Association for Cancer Research

Wieduwilt MJ, Valles F, Issa S, Behler CM, Hwang J, McDermott M, Treseler P, O'Brien J, Shuman MA, Cha S, Damon LE, Rubenstein JL

Upregulation of Cyclin B1 by miRNA and its implications in cancer.

Nucleic acids research

Huang V, Place RF, Portnoy V, Wang J, Qi Z, Jia Z, Yu A, Shuman M, Yu J, Li LC

Time-resolved single-step protease activity quantification using nanoplasmonic resonator sensors.

ACS nano

Sun C, Su KH, Valentine J, Rosa-Bauza YT, Ellman JA, Elboudwarej O, Mukherjee B, Craik CS, Shuman MA, Chen FF, Zhang X

The unfolded protein response during prostate cancer development.

Cancer metastasis reviews

So AY, de la Fuente E, Walter P, Shuman M, Bernales S

Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kadoch C, Dinca EB, Voicu R, Chen L, Nguyen D, Parikh S, Karrim J, Shuman MA, Lowell CA, Treseler PA, James CD, Rubenstein JL

Differential gene expression in central nervous system lymphoma.

Blood

Rubenstein JL, Shen A, Batchelor TT, Kadoch C, Treseler P, Shuman MA

Protein biomarker identification in the CSF of patients with CNS lymphoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Roy S, Josephson SA, Fridlyand J, Karch J, Kadoch C, Karrim J, Damon L, Treseler P, Kunwar S, Shuman MA, Jones T, Becker CH, Schulman H, Rubenstein JL

Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Rubenstein JL, Fridlyand J, Abrey L, Shen A, Karch J, Wang E, Issa S, Damon L, Prados M, McDermott M, O'Brien J, Haqq C, Shuman M

The epidemiology of prostate cancer--with a focus on nonsteroidal anti-inflammatory drugs.

Hematology/oncology clinics of North America

Chan JM, Feraco A, Shuman M, Hernández-Díaz S

Gene expression and angiotropism in primary CNS lymphoma.

Blood

Rubenstein JL, Fridlyand J, Shen A, Aldape K, Ginzinger D, Batchelor T, Treseler P, Berger M, McDermott M, Prados M, Karch J, Okada C, Hyun W, Parikh S, Haqq C, Shuman M

Symposium on androgen action in prostate cancer.

Cancer research

Tindall D, Horne FM, Hruszkewycz A, Mohla S, Shuman M, Wang Z, Kantoff P

Quinine/quinidine-induced thrombocytopenia: a great imitator.

Archives of internal medicine

Reddy JC, Shuman MA, Aster RH

Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells.

Biological chemistry

Bhatt AS, Takeuchi T, Ylstra B, Ginzinger D, Albertson D, Shuman MA, Craik CS

Patterns of protease production during prostate cancer progression: proteomic evidence for cascades in a transgenic model.

Prostate cancer and prostatic diseases

Bok RA, Hansell EJ, Nguyen TP, Greenberg NM, McKerrow JH, Shuman MA

Hemorrhage and VEGF expression in a case of primary CNS lymphoma.

Journal of neuro-oncology

Rubenstein J, Fischbein N, Aldape K, Burton E, Shuman M

Urokinase plasminogen activator amino-terminal peptides inhibit development of the rat ventral prostate.

Differentiation; research in biological diversity

Elfman F, Bok R, Conn M, Shuman M, Cunha G

Vascular endothelial growth factor and basic fibroblast growth factor urine levels as predictors of outcome in hormone-refractory prostate cancer patients: a cancer and leukemia group B study.

Cancer research

Bok RA, Halabi S, Fei DT, Rodriquez CR, Hayes DF, Vogelzang NJ, Kantoff P, Shuman MA, Small EJ

Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption.

Neoplasia (New York, N.Y.)

Rubenstein JL, Kim J, Ozawa T, Zhang M, Westphal M, Deen DF, Shuman MA

Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue.

Proceedings of the National Academy of Sciences of the United States of America

Takeuchi T, Shuman MA, Craik CS

Neutralizing anti-vascular endothelial growth factor antibody inhibits further growth of established prostate cancer and metastases in a pre-clinical model.

The Journal of urology

Melnyk O, Zimmerman M, Kim KJ, Shuman M

Interferon-induced thrombocytopenia: is it time for thrombopoietin.

Hepatology (Baltimore, Md.)

Martin TG, Shuman MA

Death-defying yeast identify novel apoptosis genes.

Cell

Shaham S, Shuman MA, Herskowitz I

Decreased prostate cancer cell migration by inhibition of the insulin-like growth factor II/Mannose-6-Phosphate receptor.

Urologic oncology

Evans CP, Elfman F, Cunha G, Shuman MA

Inhibition of prostate cancer neovascularization and growth by urokinase-plasminogen activator receptor blockade.

Cancer research

Evans CP, Elfman F, Parangi S, Conn M, Cunha G, Shuman MA

Thrombopoietin levels in patients with cirrhosis before and after orthotopic liver transplantation.

Annals of internal medicine

Martin TG, Somberg KA, Meng YG, Cohen RL, Heid CA, de Sauvage FJ, Shuman MA

Circulating thrombopoietin concentrations in thrombocytopenic patients, including cancer patients following chemotherapy, with or without peripheral blood progenitor cell transplantation.

British journal of haematology

Meng YG, Martin TG, Peterson ML, Shuman MA, Cohen RL, Wong WL

Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice.

Cancer research

Min HY, Doyle LV, Vitt CR, Zandonella CL, Stratton-Thomas JR, Shuman MA, Rosenberg S

Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth.

Cancer research

Melnyk O, Shuman MA, Kim KJ

Co-expression of urokinase, urokinase receptor and PAI-1 is necessary for optimum invasiveness of cultured lung cancer cells.

International journal of cancer

Liu G, Shuman MA, Cohen RL

Characterization of a human Kaposi's sarcoma cell line that induces angiogenic tumors in animals.

AIDS (London, England)

Herndier BG, Werner A, Arnstein P, Abbey NW, Demartis F, Cohen RL, Shuman MA, Levy JA

The urokinase receptor is expressed in invasive breast cancer but not in normal breast tissue.

Cancer research

Bianchi E, Cohen RL, Thor AT, Todd RF, Mizukami IF, Lawrence DA, Ljung BM, Shuman MA, Smith HS

Endocytosis of fibrinogen into megakaryocyte and platelet alpha-granules is mediated by alpha IIb beta 3 (glycoprotein IIb-IIIa)

Blood

Handagama P, Scarborough RM, Shuman MA, Bainton DF

Prevention of metastasis by inhibition of the urokinase receptor.

Proceedings of the National Academy of Sciences of the United States of America

Crowley CW, Cohen RL, Lucas BK, Liu G, Shuman MA, Levinson AD

Kistrin, an integrin antagonist, blocks endocytosis of fibrinogen into guinea pig megakaryocyte and platelet alpha-granules.

The Journal of clinical investigation

Handagama P, Bainton DF, Jacques Y, Conn MT, Lazarus RA, Shuman MA

Differential effect of platelets on plasminogen activation by tissue plasminogen activator, urokinase, and streptokinase.

Thrombosis research

Gao SW, Morser J, McLean K, Shuman MA

A nonradioactive assay for type IV collagen degradation.

Analytical biochemistry

Wilkinson MJ, Cohen RL, Shuman MA

Identification of an abnormal gene for the GPIIIa subunit of the platelet fibrinogen receptor resulting in Glanzmann's thrombasthenia.

Blood

Bray PF, Shuman MA

The origin of platelet alpha-granule proteins.

Progress in clinical and biological research

Handagama PJ, Shuman MA, Bainton DF

Anaphylactoid reactions to vascular graft material presenting with vasodilation and subsequent disseminated intravascular coagulation.

Anesthesiology

Roizen MF, Rodgers GM, Valone FH, Lampe GH, Benefiel DJ, Gelman S, Rapp J, Weiler JM, Ota M, Shuman MA

Incorporation of intravenously injected albumin, immunoglobulin G, and fibrinogen in guinea pig megakaryocyte granules.

The Journal of clinical investigation

Handagama PJ, Shuman MA, Bainton DF

Immunogold-surface replica study of ADP-induced ligand binding and fibrinogen receptor clustering in human platelets.

The American journal of anatomy

Isenberg WM, McEver RP, Phillips DR, Shuman MA, Bainton DF

Effects of cellular transformation on expression of plasminogen activator inhibitors 1 and 2. Evidence for independent regulation.

The Journal of biological chemistry

Cohen RL, Niclas J, Lee WM, Wun TC, Crowley CW, Levinson AD, Sadler JE, Shuman MA

Tissue plasminogen activator in cultured human trabecular meshwork cells. Predominance of enzyme over plasminogen activator inhibitor.

Investigative ophthalmology & visual science

Shuman MA, Polansky JR, Merkel C, Alvarado JA

Identification of normal human peripheral blood monocytes and liver as sites of synthesis of coagulation factor XIII a-chain.

Blood

Weisberg LJ, Shiu DT, Conkling PR, Shuman MA

The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering.

The Journal of cell biology

Isenberg WM, McEver RP, Phillips DR, Shuman MA, Bainton DF

Activation of plasminogen by tissue plasminogen activator on normal and thrombasthenic platelets: effects on surface proteins and platelet aggregation.

Blood

Stricker RB, Wong D, Shiu DT, Reyes PT, Shuman MA

Congenital thrombotic disorders.

American journal of hematology

Rodgers GM, Shuman MA

Biogenesis of the platelet receptor for fibrinogen: evidence for separate precursors for glycoproteins IIb and IIIa.

Proceedings of the National Academy of Sciences of the United States of America

Bray PF, Rosa JP, Lingappa VR, Kan YW, McEver RP, Shuman MA

Immunohistochemical localization of membrane and alpha-granule proteins in human megakaryocytes: application to plastic-embedded bone marrow biopsy specimens.

Blood

Beckstead JH, Stenberg PE, McEver RP, Shuman MA, Bainton DF

Thrombin-cellular interactions.

Annals of the New York Academy of Sciences

Shuman MA

Topographic distribution of a granule membrane protein (GMP-140) that is expressed on the platelet surface after activation: an immunogold-surface replica study.

Blood cells

Isenberg WM, McEver RP, Shuman MA, Bainton DF

A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation.

The Journal of cell biology

Stenberg PE, McEver RP, Shuman MA, Jacques YV, Bainton DF

Acquired Bernard-Soulier syndrome. Evidence for the role of a 210,000-molecular weight protein in the interaction of platelets with von Willebrand factor.

The Journal of clinical investigation

Stricker RB, Wong D, Saks SR, Corash L, Shuman MA

Optimal techniques for the immunocytochemical demonstration of beta-thromboglobulin, platelet factor 4, and fibrinogen in the alpha granules of unstimulated platelets.

The Histochemical journal

Stenberg PE, Shuman MA, Levine SP, Bainton DF

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Marc Shuman, MD